Digestive Enzyme Blend
- BioCore®Pro is a blend of specially selected proteases from a variety of sources. This unique combination of proteases is able to optimize protein digestion throughout the entire digestive tract. Because the stomach is of paramount importance in the initial breakdown of protein, BioCore®Pro is formulated to have optimum activity in the acidic environment of the stomach to begin the breakdown of protein. Yet it has the unique ability to continue to break down protein throughout the full pH range of the digestive tract. This means our BioCore®Pro blend of proteases is active throughout the digestive tract and can completely break down proteins in conjunction with the body’s own enzymes.
- BioCore®Lipo is a unique combination of lipases. It is included in CHP’s proprietary digestive enzyme blend to address the problems associated with the consumption of fat. Excessive intake of fat can contribute to the systemic problems that can cause a variety of gastrointestinal problems including heartburn. Biocore®Lipo is formulated with highly concentrated lipases with guaranteed, standardized activity levels. These unique lipases are especially resistant to stomach acid and active in a wide pH range. This ensures activity in both the stomach and small intestines to maximize fat digestion.
- Amylases (Acid Maltase, Glucoamylase, Invertase, Lactase) are the enzymes required to breakdown carbohydrates. CHP’s digestive enzyme blend not only contains the basic amylase, but also includes acid maltase and glucoamylase to ensure complete digestion of carbohydrates. Invertase helps ensure proper utilization of sugars, and lactase is included to digest and utilize milk sugars.
- Cellulase is required to breakdown fibers and complex carbohydrates. Including cellulase in the blend helps to maximize the release of nutrients, especially minerals from the foods we eat.
The CHP proprietary probiotics blend includes thirteen different species of probiotics to optimize the microflora of the digestive tract. Each of the species included in this blend provide specific health benefits as demonstrated in published clinical trials.
- Bifidobacterium infantis also called B. lactis, gets its name because it is the dominant bacteria in the intestine of healthy breast-fed babies. Most authorities attribute much of the superior disease resistance of breast-fed babies to this species.
- Bifidobacterium longum is among the probiotics that have been shown to improve immune responses in animals and humans. Increases in lymphocyte production, interleukin 1, 2 and 6, tumor necrosis factor, prostaglandin E1 production, serum total protein, albumin, globulin and gamma interferon have all been observed when this species is used as a supplement.
- Lactobacillus bulgaricus is used to ferment natural yogurt and augments acidophilus in a protective colonization of the intestines. Populations that consume large quantities of yogurt report increased longevity and health and prolonged functioning.
- Bifidobacterium bifidum is backed by extensive literature describing its many benefits.
- Lactobacillus acidophilus is included in this blend as Dr. Khem Shahani’s patented DDS-1 strain. This special strain of L. acidophilus can survive in temperatures that destroy many other strains and it is resistant to the high concentrations of bile salts secreted by the gall bladder.
- Lactobacillus brevis has been shown to produce a number of compounds (including Lactobacillin and Lactobrevin) that are active against a wide variety of pathogenic organisms.
- Lactobacillus casei complements the growth of L. acidophilus, is a producer of the enzyme amylase (a carbohydrate digesting enzyme) and has been researched for its potential to improve digestion, and reduce lactose intolerance and constipation.
- Lactobacillus lactis has been shown to stimulate the lactoperoxide thocyanate system in the intestine, which reduces the ability of E. coli to survive.
- Lactobacillus plantarum constantly wages warfare with the “bad” bacteria and has the distinctive feature of synthesizing L-lysine, which strongly supports the immune system.
- Lactobacillus reuteri has been extensively researched by one of the world’s top authorities, Dr. Marvin Spec. demonstrating that this species is a powerful producer of natural antiobiotics.
- L. rhamnosus has the ability to inhibit the growth of harmful bacteria and has been researched for its potential benefits to the genitourinary tract.
- Lactobacillus salivarius has been shown to help in almost all chronic conditions related to the bowel and is especially effective in producing digestive enzymes in the intestines.
- Streptococcus thermophilus produces lactase and is very efficient in breaking down milk products.
Prebiotic and Herbal Blend
This unique blend combines the prebiotic benefits of inulin with the soothing effects of traditional herbs and patented, stabilized glutamine. Prebiotics are nutrients that promote the growth of friendly bacteria (probiotics) and enhance their colonization in the digestive tract.
- Beet Root is rich in antioxidants and has natural anti-inflammatory properties. It has been used in herbal medicine as part of detoxification programs to support liver and digestive function.
- Chamomille is traditionally used for its soothing, anti-inflammatory properties including digestive conditions and even infant colic.
- Ginger is well known for its traditional use to help with nausea and stomach upset. Modern research not only confirms the benefits but shows it may also have natural anti-bacterial properties.
- Glutamine is an amino acid that is essential for healthy intestinal cells and has been researched for its potential in reducing inflammation in the digestive tract. It is included in this formula as patented, stabilized magnesium-glycyl-glutamine.
- Inulin is a soluble fiber that acts as a prebiotic promoting the growth of friendly bacteria (probiotics) in the digestive tract. Inulin is also known to enhance the absorption of certain nutrients, especially calcium and magnesium.
- Peppermint has been used for centuries both for its unique flavor and its potential health benefits. Most recently it ha been studied for its potential benefits in helping irritable bowel syndrome.
Enzyme Research – Digestive Health and Nutrient Bioavailablity
Ehren J et al. A food-grade enzyme preparation with modest gluten detoxification properties. PLosOne 2009; 4(7):e6313.
Gass J et al. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology 2007; 133(2):472-80.
Glade MJ et al. Improvement in protein utilization in nursing-home patients on tube feeding supplemented with an enzyme product derived from Aspergillus niger and bromelain. Nutrition 2001; 17:348-50.
Layer P and Keller J. Lipase supplementation therapy: standards, alternatives and perspectives. Pancreas 2003; 26(1):1-7.
Phelan JJ et al. Coeliac disease: the abolition of gliadin toxicity by enzymes from Aspergillus niger. Clin Sci Mol Med 1977; 53: 35-43.
Popiela T et al. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek 2000; 57(Suppl) 5:142.
Popiela T et al. Influence of a complementary treatment with oral enzymes on patients with colorectal cancers – an epidemiological retrolective cohort study. Cancer Chemother Pharmacol 2001 Jul; 47(Suppl):S55-S63.
Rosado JL et al. Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime. Gastroenterology 1984;87:1072-1082.
Roxas M. The role of enzyme supplementation in digestive disorders. Alt Med Rev 2008; 13(4):307-14.
Sandberg AS. Bioavailability of minerals in legumes. Br J Nutr 2002; 88(Suppl 3):S281-S285.
Sandberg AS et al. Dietary Aspergillus niger phytase increases iron absorption in humans. J Nutr 1996; 126:476-480.
Stahl CH et al. Phytase improves iron bioavailability for hemoglobin synthesis in young pigs. J Anim Sci 1999; 77: 2135-2142.
Stepniak D et al. Highly efficient gluten degradation with a newly identified propyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol. 2006; 291(4):G621-9.
Probiotics and Eczema
Isolauri et al. Probiotics in the management of atopic eczema. Clin Exp Allergy 2000; 30(11):1604-1610.
Kalliomaki et al. “Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial.” Lancet 2001; 357:1076-1079
Kirjavainen PV et al. Probiotic bacteria in the management of atopic disease: underscoring the importance of viability. J Pediatr Gastroenterol Nutr 2003; 36(2):223-227.
Paterson et al. Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. Allergy 2006; 61(4):431-437.
Rosenfeldt V. et al. Effect of probiotics Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 2003; 111(2):389-395.
Viljanen M. et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 2005; 60(4):494-500.
Weston S et al. Effects of probiotics on atopic dermatitis: a randomized controlled trial. Arch Dis Child 2005; 90(9): 892-897.
Probiotics and GI Problems
Bergonzelli GE et al. Probiotics as a treatment strategy for gastrointestinal diseases? Digestion 2005; 72(1):57-68.
Bezkorovainy A. Probiotics: determinants of survival and growth in the gut. Am J Clin Nutr 2001; 73:399S-405S.
Bjorksten B. The gut microbiotia and potential health effects of intervention. Nestle Ntr Workshop Ser Pediatr Program 2006; 57:81-89.
Broekart IJ and Walker WA. Probiotics and chronic disease. J Clin Gastroenterol 2006; 40(3):270-274.
Broekaert IJ and Walker WA. Probiotics as flourishing benefactors for the human body. Gastroenterol Nurs 2006; 29(1):26-34.
Doron S and Gorbach SL. Probiotics: their role in the treatment and prevention of disease. Expert Rev Anti Infect Ther 2006; 4(2):261-275.
Floch MH et al. Recommendations for probiotics use. J Clin Gastroenterol 2006; 40(3):275-278.
Probiotics and Immunity
Arunachalam K. et al. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis. Eur J Clin Nutr 2000; 54(3):263-267.
Cunningham-Rundles S. et al. Probiotics and immune response. Am J Gastroenterol 2000; 95(1 suppl):S22-S25.
Delcenserie V et al. Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol 2008;10(1-2):37-54.
Ezendam J and VanLoveren H. Probiotics: immunomodulation and evaluation of safety and efficacy. Nutr Rev 2006; 64(1):1-14.
MacDonald TT and Gordon JN. Bacterial regulation of intestinal immune responses. Gastroenterol Clin North Am 2005; 34(3):401.
Madsen K. Probiotics and the immune response. J Clin Gastroenterol 2006; 40(3):232-234.
Matsuzaki T and Chin J. Modulating immune responses with probiotics bacteria. Immunol Cell Biol 2000; 78(1):67-73.
Rautava S et al. Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Pediatr Res 2006; 60(2):221-224.
Resta-Lenert S. and Barret KE. Probiotics and cemmensals reverse TNF-alpha and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology 2006; 130(3):731-746.
Schiffirin EJ et al. Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bateria. J Dairy Sci 1995; 78(3):491-497.
Schriffirin EJ et al. How can we impact the immune system with pre- and probiotics? Nestle Nutr Workshop Ser Clin Perform Programme 2005; 10:203-213.
Spanhaak S. et al. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr 1998; 52(12):899-907.
Tubelius P et al. Increasing work-place healthiness with the probiotics Lactobacillus reuteri: a randomized, double-blind placebo-controlled study. Environ Health 2005; 4:25.
Probiotics and lactose intolerance
Montalto M. et al. Management and treatment of lactose malabsorption. World J Gastroenterol 2006; 12(2):187-191.
Levri KM et al. Do probiotics reduce adult lactose intolerance? A systematic review. J Fam Pract 2005; 54(7):613-620.
Zhong Y et al. Effect of probiotics and yogurt on the colonic microflora in subjects with lactose intolerance. Wei Sheng Yan Jui 2006; 35(5):587-591.
Probiotics and diarrhea
Alam S and Bhatnagar S. Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea. Indian J Pediatr 2006; 73(8):693-696.
Brusner O et al. Effect of a milk formula with probiotics on the intestinal microbiota of infants after an antibiotic treatment. Pediatr Res 2006; 59(3):451-456.
Can M et al. Prohpylactic Saccharomyces boulardii in the prevention of antiobitic associated diarrhea: a prospective study. Med Sci Monit 2006; 12(4):PI19-22.
Correa NB et al. A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antiobiotic-associated diarrhea in infants. J Clin Gastroenterol 2005; 39(5):385-389.
Davidson GP. Passive protection against diarrheal disease. J Pediatr Gastroenterol Nutr 1996; 23(3):207-212.
deRoos NM. And Katan MB. Effects of probiotics bacteria on diarrhea, lipid metabolism and carcinogenesis: a review of papers published between 1988 and 1998. Am J Clin Nutr 2000; 71(2):405-411.
Hawrelak JA et al. Is lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhea: a systematic review. Digestion 2005; 72(1):51-56.
Johnston BC et al. Probiotics for pediatric antiobiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials. CMAJ 2006; 175(4):377-383.
Johnston BC et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 2007; 18(2):CD004827.
Katz JA. Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium defficle diarrhea. J Clin Gastroenterol 2006; 40(3):249-255.
Meier RF. Probiotics: a new treatment for antiobiotic-associated bacteria? Digestion 2005; 72(1):49-50.
Rosenfeldt V. et al. Effect of probiotics Lactobacillus strains in young children hospitalized with acute diarrhea. Pediatr Infect Dis J 2002; 21(5):411-416.
Rosenfeldt V et al. Effect of probiotics Lactobacillus strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers. Pediatr Infect Dis J 2002; 21(5):417-419.
Salazar LE et al. Lactobacillus casei strain GG in the treatment of infants with acute watery diarrhea: a randomized, double-blind, placebo controlled clinical trial. BMC Pediatr 2004; 4:18.
Szajewska H and Mrukowicz JZ. Probiotics in the treatment and prevention of acute infections diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr 2001; 33(Suppl 2):S17-S25.
Uydens P and Debeuckelaere S. Efficacy of SF 68 in the treatment of acute diarrhea. A placebo-controlled trial. Scand J Gastroenterol 1996; 31(9):887-891.
Van Niel CW et al. Lactobacillus Therapy for Acute Infections Diarrhea in Children: A Meta-Analysis. Pediatrics 2002; 109(4):678-684.
Probiotics & H-Pylori/Ulcers
Aiba Y et al. Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotics in a gnotobiotic murine model. Am J Gastroenterol 1998; 93(11):2097-2101.
Cremonin F et al. Effect of different probiotics preparations on anti-helicobacter pylori therapy related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97(11):2744-2749.
Michetti P et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii)La1 on Helicobacter pylori infection in humans. Digestion 1999;60(3)203-209.
Sheu BS et al. Impact of supplement with Lactobacillus and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2002; 16(9):1669-1675.
Sheu BS et al. Pretreatment with Lactobacillus and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 2006; 83(4):864-869.
Wang KY et al. Effects of ingesting Lactobacillus and Bifidobacterium containing yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr 2004; 80(3):737-741.
Probiotics and IBS (Irritable Bowel Syndrome)
Drouault-Holowacz S et al. A double blind randomized controlled trial of probiotics combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol 2008; 32(2):147-152.
Fan YJ et al. A probiotics treatment contain Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial. J Zhejang Univ Sci B 2006; 7(12):987-991.
Kim HJ et al. A randomized controlled trial of probiotics combination VSL#3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil 2005; 17(5):687-696.
Maden JA et al. A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 2002; 88(Suppl 1):S67-S72.
Niv E et al. The efficacy of Lactobacillus reuteri ATC 55730 in the treatment of patients with irritable bowel syndrome – a double blind, placebo-controlled, randomized study. Clin Nutr 2005; 24(6):925-931.
Nobaek S. et al. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol 2000; 95(5):1231-1238.
O’Mahony L. et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationships to cytokine profiles. Gastroenterology 2005; 128(3):541-551.
O’Sullivan MA and O’Morain CA. Bacterial supplementation in the irritable bowel syndrome. A randomized double-blind placebo-controlled crossover study. Dig Liver Dis 2000; 32(4):294-301.
Saggioro A. Probiotics in the treatment of irritable bowel syndrome. J Clin Gastroenterol 2004; 38(6 suppl):S104-S106.
Whorwell PJ et al. Efficacy of an encapsulated probitoic Bifidobacterium infantitis 35624 in women with irritable bowel syndrome. Am J Gastroenterol 2006; 101(7):1581-1590.
Abrams SA, Griffin IJ and Hawthorne KM. Young adolescents who respond to an inulin-type fructan substantially increase total absorbed calcium and daily calcium accretion to the skeleton. J Nutr 2007; 137(11 suppl):2524S-2526S.
Abrams SA et al. An Inulin-Type Fructan Enhances Calcium Absorption Primarily via an Effect on Colonic Absorption in Humans. J Nutr. 2007;137(10):2208-12.
Bodera P. Influence of prebiotics on the human immune system (GALT). Recent Pat Inflamm Allergy Drug Discov. 2008;2(2):149-53.
deVresse M. Health benefits of probiotics and prebiotics in women. Menopause Int. 2009;15(1):35-40.
Gibson GR et al. Prebiotics and resistance to gastrointestinal infections. Brit J Nutr 2005; 93 (Suppl 1):S31–S34.
Guarner F. Prebiotics in inflammatory bowel diseases. Br J Nutr. 2007; 98(Suppl 1):S85-9.
Holloway L et al. Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women. Brit J Nutr 2007; 97(2):365-372.
Kelly G, Inulin-Type Prebiotics: A Review (Part 1). Alt Med Rev 2008; 13(4):315
Kelly G. Inulin-Type Prebiotics: A Review (Part 2). Alt Med Rev 2009; 14(1):36
Jenkins DJ et al. Inulin, oligofructose and intestinal function. J Nutr. 1999;129(7 Suppl):1431S-3S.
Kolida S et al. Prebiotic effects of inulin and oligofructose. Br J Nutr. 2002;87(Suppl 2):S193-7.
Leenen CH and Dieleman LA. Inulin and oligofructose in chronic inflammatory bowel disease. J Nutr 2007;137(11 Suppl):2572S-2575S.
Looijer-van Langen MA and Dieleman LA. Prebiotics in chronic intestinal inflammation. Inflamm Bowel Dis. 2009;15(3):454-62.
Meyer D and Stasse-Wolthuis M. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. Eur J Clin Nutr. 2009; 63(11):1277-89.
Watzl B, Girrbach S and Roller M. Inulin, oligofructose and immunomodulation. Br J Nutr 2005; 93(Suppl 1):S49-55.
Chen JC et al. Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice. J Agric Food Chem 2007-55(21):8390-8397.
Ernst E and Pittler MH. Efficacy of Ginger for nausea and vomiting: a systematic review of randomized clinical trials. Brit J Anaesth 2000; 84 (3): 367-371.
Langner E., Greifenberg S. and Gruenwald J. Ginger: history and use. Adv Ther 1998; 15(1):25-44.
Shariatpanahi ZV et al. Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit. J Crit Care 2010 Feb 9. epub ahead of print.
Smith C et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004; 103(4):639-45.
White B. Ginger: An overview. Am Fam Physician 2007;75:1689-91
Chang FY and Lu CL. Treatment of irritable bowel syndrome using complementary and alternative medicine. J Chin Med Assoc 2009; 72(6):294-300.
Ford AC et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ 2008; 337:a2313
Inamori M et al. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time 13C breath (BreathID system). J Gastroenterol 2007; 42(7):539-42. Epub.
McKay DL and Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res 2006; 20(8):619-633.
Shen YH and Nahas R. Complementary and alternative medicine for treatment of irritable bowel syndrome.Can Fam Physician 2009; 55(2):143-148.
No author listed. Herbal remedies for dyspepsia: peppermint seems effective. Prescrire Int 2008; 17(95):121-3.
Srivastava JK, Pandey M and Gupta S. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci 2009; 85(19-20):663-9.
Lenaerts K et al. Glutamine regulates the expression of proteins with a potential health-promoting effect in human intestinal Caco-2 cells. Proteomics 2006; 6(8):3454-2464.
Liboni KC et al. Glutamine modulates LPS-induced IL-8 production through IkB/NF-kB in human fetal and adult intestinal epithelium. J. Nutr. 135: 245–251, 2005.
Noe JE. L-glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective. Integr Cancer Ther 2009; 8(4):409-415.
Sukhotnik I et al. Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats. Digestion 2009; 79(1):5-13.
Sukhotnik I et al. Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat. J Surg Res 2007; 143(2):379-384.
Wischmever PE et al. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 1997; 272(4 pt 1):G879-84.
Yalcin SS et al. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatric Gastroenterol Nutr 2004; 38(5):494-501.
Lee CH et al. Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutr Cancer 2005; 53(1):91-103.
Wettasinghe M. et al. Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. J Agric Food Chem 2002; 50(23):6704-9.
Zielinska-Pryziemska M. et al. In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals. Phytother Res 2009; 23(1):49-55.